"THE MEDICINAL CHEMISTRY VALUE OF PIPERAZINE RINGS AND BOC PROTECTION"

Introduction 1-BOC Piperazine (tert-Butyl 4-piperazinecarboxylate) is a widely used protected amine intermediate in pharmaceutical and chemical research. The BOC (tert-butyloxycarbonyl) group acts as a protecting group on the nitrogen of the piperazine ring, enabling selective reactions and minimizing undesired side reactions during synthesis.